FYN

Across TCGA pan-cancer cohorts, FYN RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated FYN data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher FYN RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated FYN expression acts as an unfavorable survival marker, although some lineages such as LIHC and KIRC show a favorable association.

LIHC, KIRC, and LUAD are the cancer types where FYN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Quartile	All	0.650	0.432	<.001	97	view →
KIRC	OS	Median	All	0.721	0.537	<.001	90	view →
LUAD	OS	Median	II,III,IV	0.787	0.630	<.001	85	view →
HNSC	DFS	Median	III,IV	0.670	0.506	.001	63	view →
UCS	DFS	Median	II,III,IV	0.614	0.138	<.001	58	view →
PAAD	OS	Quartile	II,III,IV	0.712	0.383	.002	35	view →
KIRP	DFS	Tertile	II,III,IV	0.487	1.000	.004	32	view →
UVM	DFS	Tertile	III,IV	0.845	0.404	.005	26	view →
LUSC	OS	Quartile	III,IV	0.312	0.646	.012	22	view →
LGG	OS	Quartile	All	0.935	0.800	.001	21	view →
READ	DFS	Quartile	All	0.331	0.664	.006	15	view →
SKCM	OS	Quartile	All	0.933	0.843	.003	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

FYN–LIHC (DFS)

Open the LIHC breakdown →