FYN

Across TCGA patient cohorts, FYN mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FYN-associated genes across cancer lineages are Caspase-7-cleavedD198, eEF2, and MEK1. Each is linked with FYN in more than 2 cancer types. Because this analysis shows association rather than direction, both FYN-to-partner and partner-to-FYN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by FYN-low versus FYN-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FYN→partner) and Y-score (partner→FYN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.328	+3.467	<.001	.002	3	3
UCEC	eEF2 →	+0.358	+2.115	.002	.016	3	2
UCEC	MEK1 →	+0.512	+2.201	<.001	<.001	3	2
UCEC	p21 →	+0.159	+3.807	.013	<.001	3	2
UCEC	ATM →	-0.559	-2.201	<.001	<.001	3	2
UCEC	Chk2_pT68 →	-0.148	-2.160	.017	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Caspase-7-cleavedD198 by FYN expression — COAD

Explore this box plot interactively →