FXYD4

Across TCGA patient cohorts, FXYD4 mutation is significantly associated with the RNA expression of many other genes, with 690 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FXYD4-associated genes across cancer lineages are RNU6-1211P, PPP4C, and CCT5. Each is linked with FXYD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both FXYD4-to-partner and partner-to-FXYD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1211P grouped by FXYD4-low versus FXYD4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FXYD4→partner) and Y-score (partner→FXYD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-1211P →	+0.283	+7.816	<.001	.008	3	1
UCEC	PPP4C →	+0.455	+3.502	.006	.002	3	1
UCEC	CCT5 →	+0.709	+3.376	.005	.004	3	1
UCEC	ZNF18 →	+0.470	+3.202	.006	.009	3	1
UCEC	DFFA →	+0.615	+3.217	<.001	.009	3	1
UCEC	SNRNP25 →	+0.536	+3.534	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 690 associations by consensus.

RNU6-1211P by FXYD4 expression — SKCM

Explore this box plot interactively →