FXYD4

Across TCGA pan-cancer cohorts, FXYD4 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated FXYD4 data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher FXYD4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FXYD4 expression acts as an unfavorable survival marker, although some lineages such as UCS and BLCA show a favorable association.

ESCA, UVM, and LUSC are the cancer types where FXYD4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Tertile	All	0.456	1.000	.008	19	view →
UVM	OS	Tertile	All	0.708	0.924	.008	18	view →
LUSC	OS	Tertile	II,III,IV	0.298	0.472	.010	11	view →
BRCA	OS	Quartile	III,IV	0.739	0.872	.019	10	view →
KIRC	DFS	Quartile	III,IV	0.528	0.741	.024	10	view →
THCA	DFS	Tertile	III,IV	0.758	0.908	.019	9	view →
UCEC	OS	Tertile	All	0.860	0.920	.040	8	view →
READ	OS	Quartile	IV	0.491	0.961	.026	8	view →
THYM	OS	Tertile	II,III,IV	0.650	1.000	.011	8	view →
MESO	OS	Tertile	IV	0.289	0.664	.039	6	view →
UCS	DFS	Quartile	II,III,IV	0.586	0.133	.004	6	view →
BLCA	DFS	Tertile	IV	0.641	0.305	.031	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

FXYD4–ESCA (OS)

Open the ESCA breakdown →