FURIN

Across TCGA patient cohorts, FURIN RNA expression is significantly associated with the protein abundance of many other proteins, with 11,948 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FURIN-associated proteins across cancer lineages are MYL6, IGF1R, and NGLY1. Each is linked with FURIN in more than 3 cancer types. Because this analysis shows association rather than direction, both FURIN-to-partner and partner-to-FURIN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FURIN versus MYL6 in GBM, with a Pearson correlation of 0.51.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FURIN→partner) and Y-score (partner→FURIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MYL6 →	+0.344	+0.492	<.001	<.001	3	4
LSCC	IGF1R →	+0.608	+0.612	.001	.001	3	4
CCRCC	NGLY1 →	-0.253	-0.289	<.001	.001	3	3
GBM	NNMT →	+1.056	+0.533	.001	.002	3	3
LSCC	PPFIBP1 →	+0.266	+0.509	<.001	<.001	3	3
UCEC	PTPN12 →	+0.299	+0.776	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,948 associations by consensus.

FURIN vs MYL6 — GBM

Explore this scatter interactively →