FURIN

Across TCGA pan-cancer cohorts, FURIN RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of FURIN’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FURIN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FURIN is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

HNSC, LUAD, and STAD are the cancer types where FURIN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FURIN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+1.335	<.001	12	view →
LUAD	All	II,III,IV	+0.867	.002	7	view →
STAD	Male	All	+1.206	<.001	6	view →
ESCA	All	All	+1.407	<.001	3	view →
BLCA	Male	III,IV	+0.949	.038	3	view →
LUSC	All	III,IV	+1.066	.040	2	view →
BRCA	All	III,IV	+0.473	.032	2	view →
KICH	Male	All	−0.485	.038	1	view →
KIRP	All	All	−0.349	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

FURIN–HNSC

Open the HNSC breakdown →