FURIN

Across TCGA patient cohorts, FURIN mutation is significantly associated with the RNA expression of many other genes, with 4,309 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FURIN-associated genes across cancer lineages are TIMM21, MED31, and LINC02099. Each is linked with FURIN in more than 2 cancer types. Because this analysis shows association rather than direction, both FURIN-to-partner and partner-to-FURIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIMM21 grouped by FURIN-low versus FURIN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FURIN→partner) and Y-score (partner→FURIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIMM21 →	+0.483	+4.247	<.001	<.001	3	3
UCEC	MED31 →	+0.431	+2.032	<.001	<.001	3	3
UCEC	LINC02099 →	+0.036	+2.105	.004	.002	3	3
BRCA	MIR7843 →	+0.314	+4.506	.003	.009	3	2
COAD	ADAMTSL2 →	-0.770	-3.700	.005	.001	3	2
COAD	RNY4P7 →	+0.446	+2.359	.006	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,309 associations by consensus.

TIMM21 by FURIN expression — UCEC

Explore this box plot interactively →