FTMT

Across TCGA patient cohorts, FTMT mutation is significantly associated with the RNA expression of many other genes, with 2,444 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FTMT-associated genes across cancer lineages are OR10A7, CDK8P1, and ATP5F1AP7. Each is linked with FTMT in more than 1 cancer types. Because this analysis shows association rather than direction, both FTMT-to-partner and partner-to-FTMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10A7 grouped by FTMT-low versus FTMT-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FTMT→partner) and Y-score (partner→FTMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	OR10A7 →	+0.086	+5.763	<.001	.001	3	2
READ	CDK8P1 →	+0.112	+5.039	.001	.008	3	2
READ	ATP5F1AP7 →	+0.094	+5.421	<.001	.005	3	2
READ	ATP6V1E1P2 →	+0.442	+5.039	<.001	.008	3	2
UCEC	RN7SL248P →	+0.074	+3.474	<.001	<.001	3	2
UCEC	RNA5SP412 →	+0.503	+1.774	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,444 associations by consensus.

OR10A7 by FTMT expression — HNSC

Explore this box plot interactively →