FSHB

Across TCGA patient cohorts, FSHB mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible FSHB-associated genes across cancer lineages are Endothelial cells, CD4+ Tem, and Mast cells. Each is linked with FSHB in more than 1 cancer types. Because this analysis shows association rather than direction, both FSHB-to-partner and partner-to-FSHB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endothelial cells grouped by FSHB-low versus FSHB-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FSHB→partner) and Y-score (partner→FSHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Endothelial cells →	-0.041	-2.974	.023	.035	3	2
OV	CD4+ Tem →	+0.024	+5.930	<.001	.032	3	1
SKCM	Mast cells →	+0.027	+1.919	.001	.030	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Endothelial cells by FSHB expression — SKCM

Explore this box plot interactively →