FSHB

Across TCGA pan-cancer cohorts, FSHB RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated FSHB data layer compared with 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher FSHB RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FSHB expression acts as an unfavorable survival marker, although some lineages such as ESCA and BLCA show a favorable association.

COAD, SKCM, and OV are the cancer types where FSHB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	II,III,IV	0.140	0.850	<.001	36	view →
SKCM	DFS	Tertile	II,III,IV	0.497	0.696	<.001	36	view →
OV	OS	Tertile	IV	0.305	0.765	.016	18	view →
ACC	DFS	Tertile	III,IV	0.067	0.470	.018	18	view →
STAD	DFS	Tertile	III,IV	0.281	0.624	.020	18	view →
KIRP	OS	Tertile	All	0.287	0.736	.002	15	view →
ESCA	OS	Tertile	III,IV	0.869	0.367	.040	12	view →
BLCA	DFS	Tertile	All	1.000	0.309	.044	12	view →
LIHC	OS	Tertile	II,III,IV	0.118	0.696	.003	9	view →
PAAD	DFS	Tertile	All	0.733	0.261	.022	9	view →
THYM	DFS	Median	II,III,IV	0.496	0.912	.004	9	view →
LUSC	DFS	Tertile	III,IV	0.842	0.327	.023	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

FSHB–COAD (OS)

Open the COAD breakdown →