FSHB

Across TCGA pan-cancer cohorts, FSHB RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of FSHB’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FSHB RNA is repressed in tumor relative to normal tissue. In most cancer types FSHB is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and KICH are the cancer types where FSHB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FSHB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.114	<.001	11	view →
KIRP	Male	All	−0.099	<.001	11	view →
KICH	All	All	−0.144	<.001	7	view →
PRAD	All	All	+0.056	.020	2	view →
THCA	All	All	−0.004	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

FSHB–KIRC

Open the KIRC breakdown →