FRZB

Across TCGA patient cohorts, FRZB mutation is significantly associated with the RNA expression of many other genes, with 201 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRZB-associated genes across cancer lineages are MIR367, LINC02559, and DNAJB8-AS1. Each is linked with FRZB in more than 2 cancer types. Because this analysis shows association rather than direction, both FRZB-to-partner and partner-to-FRZB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR367 grouped by FRZB-low versus FRZB-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRZB→partner) and Y-score (partner→FRZB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR367 →	+0.921	+4.951	<.001	.002	3	3
CESC	LINC02559 →	+1.058	+4.757	<.001	.004	3	2
CESC	DNAJB8-AS1 →	+0.025	+3.760	.002	.007	3	2
CESC	RN7SL354P →	+0.127	+3.653	.004	.009	3	2
LUAD	ZFX-AS1 →	+0.282	+3.819	.001	.002	3	2
BRCA	RNA5SP146 →	+0.463	+5.409	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 201 associations by consensus.

MIR367 by FRZB expression — COAD

Explore this box plot interactively →