FRZB

Across TCGA pan-cancer cohorts, FRZB RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of FRZB’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where FRZB RNA is repressed in tumor relative to normal tissue. In most cancer types FRZB is over-expressed in tumor, although a few such as KICH and HNSC show the opposite, repressed pattern.

KICH, HNSC, and COAD are the cancer types where FRZB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FRZB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	IV	−3.210	<.001	11	view →
HNSC	Male	All	−2.216	<.001	10	view →
COAD	All	IV	−1.771	<.001	10	view →
KIRP	Male	All	−2.105	<.001	9	view →
LIHC	All	II,III,IV	+1.352	<.001	9	view →
KIRC	Female	All	+1.865	<.001	8	view →
THCA	All	All	−0.505	.002	7	view →
LUSC	Male	II,III,IV	−2.180	<.001	6	view →
BRCA	Female	All	−0.634	<.001	4	view →
READ	Male	All	−1.936	.005	3	view →
UCEC	All	All	−1.071	.040	2	view →
BLCA	All	All	−0.742	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

FRZB–KICH

Open the KICH breakdown →