FRG2C

Across TCGA patient cohorts, FRG2C mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRG2C-associated genes across cancer lineages are A-Raf_pS299, STAT3_pY705, and XBP1. Each is linked with FRG2C in more than 1 cancer types. Because this analysis shows association rather than direction, both FRG2C-to-partner and partner-to-FRG2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by FRG2C-low versus FRG2C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRG2C→partner) and Y-score (partner→FRG2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.111	-2.584	.046	.011	3	1
UCEC	STAT3_pY705 →	-0.394	-2.999	.001	.035	3	1
UCEC	XBP1 →	-0.199	-3.000	.002	.036	3	1
UCEC	BRCA2 →	-0.182	-2.452	.002	.020	3	1
UCEC	Chk2 →	-0.226	-2.584	.038	.011	3	1
UCEC	TIGAR →	+0.214	+1.901	.002	.031	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

A-Raf_pS299 by FRG2C expression — UCEC

Explore this box plot interactively →