FRG2C

Across TCGA pan-cancer cohorts, FRG2C RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated FRG2C data layer compared with 3 for mutation status.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher FRG2C RNA is associated with better overall survival. In most high-consensus cancer types, elevated FRG2C expression acts as an unfavorable survival marker, although some lineages such as UCS and HNSC show a favorable association.

UCS, BLCA, and SKCM are the cancer types where FRG2C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Median	II,III,IV	0.533	0.279	.014	56	view →
BLCA	DFS	Tertile	All	0.224	0.387	.008	52	view →
SKCM	OS	Median	IV	0.196	0.779	<.001	43	view →
HNSC	DFS	Median	II,III,IV	0.434	0.257	.003	41	view →
LIHC	OS	Tertile	II,III,IV	0.899	0.686	.004	40	view →
UVM	OS	Quartile	All	0.231	0.814	<.001	28	view →
PCPG	OS	Median	All	0.918	1.000	.003	16	view →
SCLC	DFS	Tertile	III,IV	0.945	0.395	.023	12	view →
THCA	DFS	Median	IV	0.497	0.942	.006	12	view →
DLBC	OS	Tertile	III,IV	0.175	0.842	.045	12	view →
KIRP	OS	Median	III,IV	0.854	0.653	.011	11	view →
ACC	DFS	Tertile	III,IV	1.000	0.295	.024	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

FRG2C–UCS (OS)

Open the UCS breakdown →