FPGT-TNNI3K

Across TCGA patient cohorts, FPGT-TNNI3K mutation is significantly associated with the RNA expression of many other genes, with 4,471 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FPGT-TNNI3K-associated genes across cancer lineages are TEDC2, ZNF274, and MYPOP. Each is linked with FPGT-TNNI3K in more than 2 cancer types. Because this analysis shows association rather than direction, both FPGT-TNNI3K-to-partner and partner-to-FPGT-TNNI3K results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEDC2 grouped by FPGT-TNNI3K-low versus FPGT-TNNI3K-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FPGT-TNNI3K→partner) and Y-score (partner→FPGT-TNNI3K) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TEDC2 →	+0.481	+2.024	.003	.005	3	3
UCEC	ZNF274 →	+0.458	+2.212	<.001	<.001	3	3
UCEC	MYPOP →	+0.334	+2.223	.003	<.001	3	3
UCEC	RAD54L →	+0.721	+3.807	<.001	<.001	3	3
UCEC	CDC45 →	+0.821	+2.638	<.001	<.001	3	3
UCEC	ZNF850 →	+0.448	+2.165	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,471 associations by consensus.

TEDC2 by FPGT-TNNI3K expression — UCEC

Explore this box plot interactively →