FPGT-TNNI3K

Across TCGA pan-cancer cohorts, FPGT-TNNI3K RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of FPGT-TNNI3K’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where FPGT-TNNI3K RNA is repressed in tumor relative to normal tissue. In most cancer types FPGT-TNNI3K is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

COAD, LUSC, and KICH are the cancer types where FPGT-TNNI3K tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FPGT-TNNI3K RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	−0.084	<.001	9	view →
LUSC	Male	II,III,IV	−0.219	<.001	8	view →
KICH	All	All	−0.166	<.001	8	view →
BRCA	All	III,IV	−0.381	<.001	6	view →
UCEC	All	All	−0.298	<.001	6	view →
BLCA	Male	All	−0.232	<.001	6	view →
THCA	All	All	−0.162	<.001	6	view →
KIRC	All	II,III,IV	+0.085	.007	5	view →
LUAD	All	III,IV	−0.195	<.001	4	view →
KIRP	All	III,IV	−0.100	.026	3	view →
LIHC	All	All	+0.020	.008	3	view →
CHOL	All	All	+0.154	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

FPGT-TNNI3K–COAD

Open the COAD breakdown →