FPGT-TNNI3K

Across TCGA pan-cancer cohorts, FPGT-TNNI3K RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated FPGT-TNNI3K data layer compared with 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FPGT-TNNI3K RNA is associated with better overall survival. In most high-consensus cancer types, elevated FPGT-TNNI3K expression acts as an unfavorable survival marker, although some lineages such as HNSC and MESO show a favorable association.

HNSC, MESO, and UVM are the cancer types where FPGT-TNNI3K RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.459	0.331	.001	109	view →
MESO	OS	Quartile	III,IV	0.608	0.272	.001	100	view →
UVM	DFS	Median	III,IV	0.208	0.740	.006	73	view →
BRCA	OS	Quartile	III,IV	0.642	0.291	.001	20	view →
KIRP	DFS	Median	IV	0.622	0.040	.006	18	view →
LIHC	OS	Quartile	II,III,IV	0.972	0.645	.005	15	view →
SKCM	OS	Quartile	IV	0.699	0.178	.001	14	view →
ESCA	OS	Median	IV	0.222	0.698	.006	12	view →
THYM	OS	Tertile	All	0.808	1.000	.018	9	view →
LGG	DFS	Quartile	All	0.777	0.886	.011	9	view →
CESC	OS	Quartile	IV	0.801	0.209	.021	6	view →
OV	OS	Median	IV	0.498	0.716	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

FPGT-TNNI3K–HNSC (OS)

Open the HNSC breakdown →