FPGT-TNNI3K

Across TCGA cell cohorts, FPGT-TNNI3K mutation is significantly associated with the RNA expression of many other genes, with 319 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FPGT-TNNI3K-associated genes across cancer lineages are KRTAP5-5, CYP4B1, and MS4A14. Each is linked with FPGT-TNNI3K in more than 1 cancer types. Because this analysis shows association rather than direction, both FPGT-TNNI3K-to-partner and partner-to-FPGT-TNNI3K results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP5-5 grouped by FPGT-TNNI3K-low versus FPGT-TNNI3K-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FPGT-TNNI3K→partner) and Y-score (partner→FPGT-TNNI3K) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	KRTAP5-5 →	+0.014	+4.772	<.001	.002	3	2
LARGE_INTESTINE	CYP4B1 →	+0.680	+2.158	<.001	.004	3	2
LARGE_INTESTINE	MS4A14 →	+0.007	+1.691	.001	.009	3	2
SOFT_TISSUE	LYPD2 →	+0.073	+4.369	<.001	.008	3	1
URINARY_TRACT	CER1 →	+0.026	+5.087	<.001	.004	3	1
OESOPHAGUS	CRYGA →	+0.043	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 319 associations by consensus.

KRTAP5-5 by FPGT-TNNI3K expression — CNS

Explore this box plot interactively →