FOXN1

Across TCGA patient cohorts, FOXN1 mutation is significantly associated with the RNA expression of many other genes, with 3,180 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXN1-associated genes across cancer lineages are MTHFD2P3, CYFIP1, and TMEM269. Each is linked with FOXN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FOXN1-to-partner and partner-to-FOXN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTHFD2P3 grouped by FOXN1-low versus FOXN1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXN1→partner) and Y-score (partner→FOXN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MTHFD2P3 →	+0.218	+5.760	<.001	.003	3	3
UCEC	CYFIP1 →	+0.518	+2.439	<.001	.001	3	2
UCEC	TMEM269 →	+0.270	+3.241	<.001	<.001	3	2
UCEC	RNA5SP412 →	+0.659	+2.049	<.001	.001	3	2
BLCA	BMP6P1 →	+0.670	+4.112	<.001	.004	3	2
STAD	MIR6882 →	+0.328	+4.090	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,180 associations by consensus.

MTHFD2P3 by FOXN1 expression — BRCA

Explore this box plot interactively →