FOXN1

Across TCGA pan-cancer cohorts, FOXN1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of FOXN1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where FOXN1 RNA is repressed in tumor relative to normal tissue. In most cancer types FOXN1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and KICH are the cancer types where FOXN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FOXN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.630	<.001	9	view →
KIRC	Male	All	−0.426	<.001	8	view →
KICH	Male	All	−0.807	<.001	7	view →
LUSC	Male	All	+2.392	<.001	6	view →
CHOL	All	All	+0.292	<.001	5	view →
HNSC	All	IV	+1.069	.022	2	view →
BRCA	All	III,IV	+0.516	.009	2	view →
LUAD	All	IV	−0.435	.021	2	view →
PRAD	All	All	−0.310	.042	2	view →
READ	All	II,III,IV	−0.739	.010	1	view →
KIRP	Male	All	−0.293	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

FOXN1–THCA

Open the THCA breakdown →