FOXL1

Across TCGA cell cohorts, FOXL1 mutation is significantly associated with the RNA expression of many other genes, with 230 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FOXL1-associated genes across cancer lineages are HAO1, GFRAL, and LRRTM3. Each is linked with FOXL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXL1-to-partner and partner-to-FOXL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HAO1 grouped by FOXL1-low versus FOXL1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXL1→partner) and Y-score (partner→FOXL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HAO1 →	+0.031	+4.276	<.001	.007	3	1
BLOOD_Leukemia	GFRAL →	+0.025	+5.569	<.001	.001	3	1
BLOOD_Leukemia	LRRTM3 →	+0.004	+4.539	<.001	.007	3	1
BLOOD_Leukemia	KRTAP3-1 →	+0.028	+4.539	<.001	.007	3	1
BLOOD_Leukemia	OR12D1 →	+0.004	+4.969	<.001	.003	3	1
BLOOD_Leukemia	C20orf141 →	+0.277	+4.276	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 230 associations by consensus.

HAO1 by FOXL1 expression — BLOOD_Leukemia

Explore this box plot interactively →