FOXL1

Across TCGA pan-cancer cohorts, FOXL1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of FOXL1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FOXL1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FOXL1 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

HNSC, STAD, and KIRC are the cancer types where FOXL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FOXL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+1.259	<.001	12	view →
STAD	Male	II,III,IV	+1.676	<.001	8	view →
KIRC	Male	IV	+0.839	<.001	8	view →
LIHC	Female	All	+0.489	<.001	7	view →
KICH	Female	All	−1.269	<.001	6	view →
CHOL	Female	All	+0.806	.006	3	view →
THCA	All	All	+0.180	.008	3	view →
ESCA	All	All	+1.527	.005	2	view →
KIRP	Male	All	−0.559	<.001	2	view →
LUSC	All	III,IV	−0.661	.028	1	view →
LUSC	Male	All	+0.458	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 10 lineages.

FOXL1–HNSC

Open the HNSC breakdown →