FOXJ2

Across TCGA patient cohorts, FOXJ2 mutation is significantly associated with the RNA expression of many other genes, with 3,130 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXJ2-associated genes across cancer lineages are MTHFD2P3, MIR4694, and RNA5SP382. Each is linked with FOXJ2 in more than 3 cancer types. Because this analysis shows association rather than direction, both FOXJ2-to-partner and partner-to-FOXJ2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTHFD2P3 grouped by FOXJ2-low versus FOXJ2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXJ2→partner) and Y-score (partner→FOXJ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTHFD2P3 →	+0.117	+2.112	.001	.001	3	4
GBM	MIR4694 →	+0.700	+5.352	<.001	.005	3	2
CESC	RNA5SP382 →	+0.302	+3.649	.009	.003	3	2
CESC	PCDH9-AS2 →	+0.083	+4.969	<.001	<.001	3	2
CESC	EEF1DP6 →	+0.153	+4.328	<.001	.001	3	2
BLCA	OR4L1 →	+0.028	+4.492	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,130 associations by consensus.

MTHFD2P3 by FOXJ2 expression — UCEC

Explore this box plot interactively →