Across TCGA patient cohorts, FOXB2 mutation is significantly associated with the RNA expression of many other genes, with 299 significant associations in total. COAD shows the largest number of these associations.

The most reproducible FOXB2-associated genes across cancer lineages are MIR760, RNU6-90P, and RNU6-522P. Each is linked with FOXB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXB2-to-partner and partner-to-FOXB2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXB2→partner) and Y-score (partner→FOXB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR760 →	+0.536	+3.282	.002	.004	3	2
UCEC	RNU6-90P →	+0.803	+4.512	<.001	<.001	3	2
COAD	RNU6-522P →	+1.028	+4.392	<.001	.006	3	2
COAD	RN7SKP191 →	+0.516	+4.721	<.001	.004	3	2
COAD	RNU6-425P →	+0.952	+4.721	<.001	.004	3	2
COAD	RNU6-74P →	+0.605	+3.843	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 299 associations by consensus.

Exploration

FOXB2 survival (RNA) · tumor vs normal (RNA) · all FOXB2 data types