Across TCGA pan-cancer cohorts, FOXB2 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of FOXB2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FOXB2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FOXB2 is over-expressed in tumor, although a few such as UCEC show the opposite, repressed pattern.

KIRC, PRAD, and UCEC are the cancer types where FOXB2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FOXB2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.040	.001	8	view →
PRAD	All	All	+0.720	<.001	2	view →
UCEC	All	All	−0.094	.047	2	view →
LUSC	All	All	+0.105	.033	1	view →
KIRP	All	All	+0.016	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: FOXB2 RNA expression & survival · all FOXB2 data types