FOLR3

Across TCGA patient cohorts, FOLR3 mutation is significantly associated with the RNA expression of many other genes, with 727 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOLR3-associated genes across cancer lineages are PSMC3IP, MIR6803, and HSPE1P23. Each is linked with FOLR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOLR3-to-partner and partner-to-FOLR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMC3IP grouped by FOLR3-low versus FOLR3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOLR3→partner) and Y-score (partner→FOLR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMC3IP →	+0.850	+3.470	<.001	.003	3	2
UCEC	MIR6803 →	+0.230	+5.156	<.001	.001	3	2
SKCM	HSPE1P23 →	+0.056	+3.990	<.001	.009	3	2
SKCM	MIR3939 →	+0.542	+3.500	<.001	<.001	3	2
UCEC	MIR6509 →	+0.459	+2.277	.005	.008	3	2
LUAD	IQCF5 →	+0.083	+4.263	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 727 associations by consensus.

PSMC3IP by FOLR3 expression — UCEC

Explore this box plot interactively →