FOLR3

Across TCGA pan-cancer cohorts, FOLR3 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of FOLR3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FOLR3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FOLR3 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

HNSC, KIRC, and KIRP are the cancer types where FOLR3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FOLR3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+4.158	<.001	12	view →
KIRC	Female	IV	−3.291	<.001	12	view →
KIRP	Male	III,IV	−3.633	<.001	11	view →
LUAD	Female	III,IV	−2.704	<.001	9	view →
THCA	Female	II,III,IV	−1.285	<.001	8	view →
LUSC	Female	All	−2.762	<.001	7	view →
KICH	All	All	−1.050	.004	6	view →
PAAD	Male	All	−1.124	.001	2	view →
LIHC	All	III,IV	−0.100	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

FOLR3–HNSC

Open the HNSC breakdown →