FOLR1

Across TCGA patient cohorts, FOLR1 mutation is significantly associated with the RNA expression of many other genes, with 108 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible FOLR1-associated genes across cancer lineages are RNU4-45P, RNA5SP424, and RNU7-11P. Each is linked with FOLR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOLR1-to-partner and partner-to-FOLR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-45P grouped by FOLR1-low versus FOLR1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOLR1→partner) and Y-score (partner→FOLR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU4-45P →	+0.319	+8.471	<.001	.005	3	2
COAD	RNA5SP424 →	+0.571	+5.602	<.001	.004	3	2
COAD	RNU7-11P →	+0.845	+5.145	.002	.007	3	2
SKCM	TEMN3-AS1 →	+0.478	+2.480	<.001	.005	3	2
SKCM	RNU6-142P →	+0.241	+3.075	<.001	<.001	3	2
BRCA	RNA5SP102 →	+0.403	+8.055	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 108 associations by consensus.

RNU4-45P by FOLR1 expression — BRCA

Explore this box plot interactively →