FOLR1

Across TCGA pan-cancer cohorts, FOLR1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated FOLR1 data layer compared with 4 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher FOLR1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated FOLR1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

KIRC, LGG, and ACC are the cancer types where FOLR1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	All	0.688	0.508	.004	53	view →
LGG	OS	Median	All	0.753	0.865	<.001	48	view →
ACC	DFS	Tertile	All	0.160	0.694	<.001	46	view →
LIHC	OS	Tertile	All	0.586	0.747	.002	35	view →
OV	DFS	Median	IV	0.358	0.561	.005	18	view →
LUSC	DFS	Quartile	II,III,IV	0.612	0.860	.002	16	view →
SKCM	OS	Median	IV	0.623	0.172	.003	16	view →
LUAD	OS	Median	All	0.746	0.617	<.001	13	view →
READ	DFS	Quartile	IV	0.357	0.912	.015	13	view →
GBM	DFS	Quartile	All	0.214	0.401	.004	12	view →
LAML	DFS	Tertile	All	0.217	0.591	.006	12	view →
BRCA	DFS	Tertile	IV	0.286	0.760	.016	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

FOLR1–KIRC (DFS)

Open the KIRC breakdown →