FNDC3B

Across TCGA patient cohorts, FNDC3B mutation is significantly associated with the RNA expression of many other genes, with 3,106 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FNDC3B-associated genes across cancer lineages are RAB11AP1, TOMM22, and MCM5. Each is linked with FNDC3B in more than 2 cancer types. Because this analysis shows association rather than direction, both FNDC3B-to-partner and partner-to-FNDC3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAB11AP1 grouped by FNDC3B-low versus FNDC3B-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FNDC3B→partner) and Y-score (partner→FNDC3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RAB11AP1 →	+0.354	+5.039	<.001	.008	3	3
UCEC	TOMM22 →	+0.379	+2.168	<.001	<.001	3	3
SKCM	MCM5 →	+0.554	+2.622	.001	.005	3	3
SKCM	POLR2C →	+0.408	+1.951	.002	.009	3	3
UCEC	SMU1 →	+0.309	+1.688	.001	.001	3	3
UCEC	DAD1 →	+0.343	+1.730	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,106 associations by consensus.

RAB11AP1 by FNDC3B expression — READ

Explore this box plot interactively →