FNDC3B

Across TCGA pan-cancer cohorts, FNDC3B RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated FNDC3B data layer compared with 12 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher FNDC3B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FNDC3B expression acts as an unfavorable survival marker, although some lineages such as SKCM and LAML show a favorable association.

MESO, BLCA, and LIHC are the cancer types where FNDC3B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.256	0.707	.002	87	view →
BLCA	DFS	Tertile	All	0.338	0.651	<.001	75	view →
LIHC	DFS	Median	All	0.464	0.615	<.001	66	view →
ACC	DFS	Tertile	All	0.386	0.822	<.001	60	view →
SKCM	OS	Tertile	All	0.409	0.245	<.001	55	view →
LGG	OS	Median	All	0.700	0.936	<.001	54	view →
PAAD	OS	Tertile	All	0.252	0.536	.001	46	view →
UVM	DFS	Tertile	III,IV	0.209	1.000	.001	46	view →
LAML	DFS	Median	All	0.583	0.347	.001	40	view →
KICH	DFS	Quartile	All	0.490	0.938	.003	35	view →
CESC	DFS	Tertile	All	0.336	0.718	<.001	34	view →
KIRP	OS	Median	III,IV	0.153	0.809	.002	31	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

FNDC3B–MESO (OS)

Open the MESO breakdown →