FNDC3B

Across TCGA pan-cancer cohorts, FNDC3B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of FNDC3B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FNDC3B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FNDC3B is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, KIRC, and STAD are the cancer types where FNDC3B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FNDC3B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+2.371	<.001	12	view →
KIRC	Female	III,IV	+1.001	<.001	12	view →
STAD	All	II,III,IV	+0.983	<.001	8	view →
KIRP	All	All	+0.595	<.001	8	view →
LUAD	All	All	+0.566	<.001	8	view →
LIHC	All	II,III,IV	+0.797	<.001	7	view →
COAD	Male	II,III,IV	+0.497	.001	7	view →
BLCA	All	All	+0.992	.002	6	view →
UCEC	All	All	+0.666	.006	6	view →
LUSC	Male	II,III,IV	+0.855	<.001	5	view →
THCA	All	All	−0.304	.013	5	view →
CHOL	All	All	+1.715	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

FNDC3B–HNSC

Open the HNSC breakdown →