FNDC3B

Across TCGA patient cohorts, FNDC3B mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FNDC3B-associated genes across cancer lineages are EGFR_pY1173, p27_pT198, and ATM. Each is linked with FNDC3B in more than 1 cancer types. Because this analysis shows association rather than direction, both FNDC3B-to-partner and partner-to-FNDC3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by FNDC3B-low versus FNDC3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FNDC3B→partner) and Y-score (partner→FNDC3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.074	+1.700	.003	.040	3	2
UCEC	p27_pT198 →	+0.098	+2.115	.003	.016	3	2
UCEC	ATM →	-0.428	-1.777	.003	.002	3	2
UCEC	Bak →	+0.186	+1.584	.019	.032	3	2
UCEC	c-Met_pY1235 →	+0.056	+1.775	.017	.007	3	2
UCEC	Cyclin-B1 →	+0.599	+2.906	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

EGFR_pY1173 by FNDC3B expression — UCEC

Explore this box plot interactively →