FNDC3B

Across TCGA cell cohorts, FNDC3B mutation is significantly associated with the RNA expression of many other genes, with 588 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FNDC3B-associated genes across cancer lineages are TTI2, ATXN10, and CNOT9. Each is linked with FNDC3B in more than 1 cancer types. Because this analysis shows association rather than direction, both FNDC3B-to-partner and partner-to-FNDC3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTI2 grouped by FNDC3B-low versus FNDC3B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FNDC3B→partner) and Y-score (partner→FNDC3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TTI2 →	+0.567	+3.628	.004	<.001	3	2
LARGE_INTESTINE	ATXN10 →	+0.930	+3.321	<.001	.002	3	2
LARGE_INTESTINE	CNOT9 →	+0.441	+3.628	.003	<.001	3	2
LARGE_INTESTINE	TATDN2 →	+0.477	+2.502	.003	.005	3	2
LARGE_INTESTINE	HLCS →	+0.735	+2.502	.001	.005	3	2
LARGE_INTESTINE	PPP4R2 →	+0.457	+2.502	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 588 associations by consensus.

TTI2 by FNDC3B expression — LARGE_INTESTINE

Explore this box plot interactively →