FMR1NB

Across TCGA cell cohorts, FMR1NB mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FMR1NB-associated genes across cancer lineages are IL9, OR1L3, and FAM47C. Each is linked with FMR1NB in more than 1 cancer types. Because this analysis shows association rather than direction, both FMR1NB-to-partner and partner-to-FMR1NB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL9 grouped by FMR1NB-low versus FMR1NB-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMR1NB→partner) and Y-score (partner→FMR1NB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	IL9 →	+0.053	+5.781	<.001	.001	3	1
SKIN	OR1L3 →	+0.029	+5.415	<.001	.004	3	1
SKIN	FAM47C →	+0.006	+4.977	<.001	.007	3	1
LARGE_INTESTINE	ZNF831 →	+0.018	+4.273	<.001	.006	3	1
LARGE_INTESTINE	TAFA1 →	+0.410	+4.273	<.001	.006	3	1
LARGE_INTESTINE	CENPVL1 →	+0.227	+4.095	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

IL9 by FMR1NB expression — BREAST

Explore this box plot interactively →