FMR1NB

Across TCGA pan-cancer cohorts, FMR1NB RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated FMR1NB data layer compared with 6 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher FMR1NB RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FMR1NB expression acts as an unfavorable survival marker, although some lineages such as COAD and TGCT show a favorable association.

KIRC, HNSC, and ESCA are the cancer types where FMR1NB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.830	0.909	<.001	155	view →
HNSC	DFS	Quartile	All	0.597	0.745	.002	119	view →
ESCA	OS	Median	II,III,IV	0.578	0.807	<.001	72	view →
KICH	DFS	Tertile	III,IV	0.264	1.000	<.001	58	view →
ACC	DFS	Tertile	III,IV	0.253	0.681	<.001	49	view →
COAD	OS	Tertile	III,IV	0.884	0.388	.003	42	view →
UCEC	DFS	Quartile	All	0.769	0.874	.001	36	view →
PAAD	DFS	Tertile	III,IV	0.275	0.794	.008	26	view →
TGCT	DFS	Tertile	All	0.814	0.477	.010	18	view →
BLCA	OS	Tertile	All	0.543	0.723	.030	11	view →
CHOL	OS	Median	All	0.921	0.589	.019	7	view →
SARC	OS	Quartile	All	0.648	0.809	.006	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

FMR1NB–KIRC (OS)

Open the KIRC breakdown →