FMC1

Across TCGA patient cohorts, FMC1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FMC1-associated genes across cancer lineages are MIR4710, SPANXC, and RNU1-17P. Each is linked with FMC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FMC1-to-partner and partner-to-FMC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4710 grouped by FMC1-low versus FMC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMC1→partner) and Y-score (partner→FMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4710 →	+0.945	+4.031	<.001	.003	3	1
UCEC	SPANXC →	+0.275	+3.759	.003	.005	3	1
UCEC	RNU1-17P →	+0.441	+3.935	<.001	.003	3	1
UCEC	RNU6-525P →	+0.402	+4.694	<.001	<.001	3	1
UCEC	RNU6-660P →	+0.527	+3.889	<.001	.004	3	1
UCEC	RNU4-16P →	+0.423	+3.638	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MIR4710 by FMC1 expression — UCEC

Explore this box plot interactively →