FMC1

Across TCGA pan-cancer cohorts, FMC1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of FMC1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where FMC1 RNA is repressed in tumor relative to normal tissue. In most cancer types FMC1 is over-expressed in tumor, although a few such as LUAD and KIRC show the opposite, repressed pattern.

LUAD, KIRC, and BRCA are the cancer types where FMC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FMC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	−0.691	<.001	7	view →
KIRC	Male	All	−0.517	<.001	6	view →
BRCA	Female	II,III,IV	−0.459	<.001	6	view →
READ	All	II,III,IV	−1.097	.008	4	view →
KICH	All	All	−0.566	<.001	4	view →
LUSC	All	III,IV	−0.651	.020	3	view →
LIHC	Male	All	+0.443	.007	3	view →
PRAD	All	All	+0.397	.002	2	view →
CHOL	All	All	−0.601	.018	1	view →
THCA	Male	All	−0.341	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

FMC1–LUAD

Open the LUAD breakdown →