FLYWCH2

Across TCGA patient cohorts, FLYWCH2 mutation is significantly associated with the RNA expression of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FLYWCH2-associated genes across cancer lineages are RNA5SP424, E2F6P1, and MRPL50P4. Each is linked with FLYWCH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FLYWCH2-to-partner and partner-to-FLYWCH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP424 grouped by FLYWCH2-low versus FLYWCH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLYWCH2→partner) and Y-score (partner→FLYWCH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP424 →	+0.308	+3.505	<.001	.005	3	2
UCEC	E2F6P1 →	+0.052	+4.660	<.001	.003	3	2
SKCM	MRPL50P4 →	+0.107	+5.513	<.001	.004	3	1
SKCM	RN7SL41P →	+0.201	+6.080	<.001	.002	3	1
BLCA	MIR378F →	+0.433	+7.640	<.001	.009	3	1
BLCA	ELOA3BP →	+0.024	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

RNA5SP424 by FLYWCH2 expression — UCEC

Explore this box plot interactively →