FLYWCH2

Across TCGA pan-cancer cohorts, FLYWCH2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of FLYWCH2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where FLYWCH2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FLYWCH2 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRP, LIHC, and KICH are the cancer types where FLYWCH2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FLYWCH2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	IV	+1.034	<.001	10	view →
LIHC	Female	II,III,IV	+1.746	<.001	9	view →
KICH	Female	All	−0.970	<.001	9	view →
BRCA	All	III,IV	+0.919	<.001	6	view →
THCA	Male	III,IV	−0.631	<.001	6	view →
HNSC	All	All	+0.258	.013	5	view →
CHOL	Female	All	+2.586	<.001	3	view →
LUSC	All	All	+0.228	.012	3	view →
PAAD	Female	All	+0.309	.041	2	view →
STAD	All	All	+0.276	.048	2	view →
ESCA	All	All	+0.397	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

FLYWCH2–KIRP

Open the KIRP breakdown →