FLYWCH2

Across TCGA pan-cancer cohorts, FLYWCH2 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated FLYWCH2 data layer compared with 6 for mass-spec protein.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher FLYWCH2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated FLYWCH2 expression acts as an unfavorable survival marker, although some lineages such as PAAD and UVM show a favorable association.

PAAD, UVM, and UCS are the cancer types where FLYWCH2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	OS	Tertile	All	0.610	0.228	<.001	67	view →
UVM	OS	Tertile	II,III,IV	0.800	0.447	.004	47	view →
UCS	OS	Median	II,III,IV	0.410	0.742	.007	40	view →
LIHC	OS	Median	All	0.451	0.682	.001	38	view →
ACC	DFS	Median	All	0.286	0.639	<.001	27	view →
KIRP	DFS	Tertile	IV	0.370	0.800	.010	27	view →
ESCA	DFS	Tertile	III,IV	0.247	0.487	.005	27	view →
KICH	OS	Quartile	II,III,IV	0.467	1.000	.005	21	view →
PRAD	DFS	Median	All	0.691	0.885	.001	18	view →
TGCT	DFS	Median	All	0.697	0.902	.001	14	view →
COAD	OS	Median	III,IV	0.717	0.357	.002	9	view →
BLCA	OS	Median	IV	0.246	0.572	.010	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

FLYWCH2–PAAD (OS)

Open the PAAD breakdown →