FLT3LG

Across TCGA cell cohorts, FLT3LG mutation is significantly associated with the mutation status of many other genes, with 870 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FLT3LG-associated genes across cancer lineages are CCN5, SOBP, and C2orf42. Each is linked with FLT3LG in more than 1 cancer types. Because this analysis shows association rather than direction, both FLT3LG-to-partner and partner-to-FLT3LG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCN5 grouped by FLT3LG-low versus FLT3LG-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLT3LG→partner) and Y-score (partner→FLT3LG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CCN5 →	+4.560	+4.309	.007	.007	1	2
BLOOD_Leukemia	SOBP →	+2.823	+3.665	.008	.008	1	2
BLOOD_Leukemia	C2orf42 →	+4.145	+4.635	.001	.001	1	2
BLOOD_Leukemia	LLGL1 →	+3.145	+3.932	.004	.004	1	2
BLOOD_Leukemia	ANXA9 →	+4.560	+4.309	.007	.007	1	2
BLOOD_Leukemia	PNLDC1 →	+4.238	+5.662	<.001	<.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 870 associations by consensus.

CCN5 by FLT3LG expression — BLOOD_Leukemia

Explore this box plot interactively →