FLT3LG

Across TCGA pan-cancer cohorts, FLT3LG RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of FLT3LG’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where FLT3LG RNA is repressed in tumor relative to normal tissue. In most cancer types FLT3LG is over-expressed in tumor, although a few such as COAD and UCEC show the opposite, repressed pattern.

COAD, UCEC, and KIRC are the cancer types where FLT3LG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FLT3LG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	−0.548	<.001	11	view →
UCEC	All	II,III,IV	−1.227	<.001	8	view →
KIRC	Male	IV	+0.668	<.001	8	view →
LUAD	Male	All	−0.508	<.001	8	view →
BRCA	Female	II,III,IV	−0.424	<.001	6	view →
LUSC	All	All	−0.319	<.001	6	view →
KICH	Male	All	−0.697	<.001	5	view →
BLCA	All	III,IV	−0.639	.003	5	view →
LIHC	Female	All	+0.493	<.001	5	view →
HNSC	All	All	+0.277	.012	4	view →
CHOL	Female	All	+1.326	.001	2	view →
READ	All	All	−0.498	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

FLT3LG–COAD

Open the COAD breakdown →