FLNB

Across TCGA cell cohorts, FLNB mutation is significantly associated with the RNA expression of many other genes, with 990 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FLNB-associated genes across cancer lineages are HMGN4, POLR1B, and IL27. Each is linked with FLNB in more than 2 cancer types. Because this analysis shows association rather than direction, both FLNB-to-partner and partner-to-FLNB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGN4 grouped by FLNB-low versus FLNB-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLNB→partner) and Y-score (partner→FLNB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HMGN4 →	+0.564	+3.489	.006	.001	3	3
LARGE_INTESTINE	POLR1B →	+0.423	+3.389	.004	.001	3	3
STOMACH	IL27 →	+0.087	+2.959	.007	.004	3	2
LUNG_NSCLC_LUAD	FBXL4 →	+0.467	+3.358	.003	.003	3	2
LUNG_NSCLC_LUAD	SIM1 →	+0.290	+2.455	.007	.005	3	2
LUNG_NSCLC_LUAD	NGLY1 →	+0.475	+3.358	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 990 associations by consensus.

HMGN4 by FLNB expression — BLOOD_Leukemia

Explore this box plot interactively →