FLNB

Across TCGA pan-cancer cohorts, FLNB RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated FLNB data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher FLNB RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FLNB expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

MESO, KIRC, and BRCA are the cancer types where FLNB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	All	0.267	0.458	<.001	114	view →
KIRC	OS	Quartile	All	0.723	0.514	<.001	75	view →
BRCA	OS	Median	III,IV	0.914	0.755	<.001	75	view →
PAAD	DFS	Tertile	All	0.362	0.604	<.001	72	view →
CESC	OS	Tertile	III,IV	0.476	0.899	.002	48	view →
ESCA	DFS	Median	III,IV	0.593	0.297	<.001	43	view →
ACC	DFS	Median	All	0.296	0.631	.002	27	view →
LIHC	DFS	Tertile	All	0.285	0.514	.005	19	view →
LUAD	OS	Quartile	III,IV	0.502	0.734	.030	15	view →
SARC	DFS	Tertile	All	0.373	0.639	.003	12	view →
OV	OS	Median	All	0.274	0.371	.008	12	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

FLNB–MESO (DFS)

Open the MESO breakdown →