FLCN

Across TCGA patient cohorts, FLCN mutation is significantly associated with the RNA expression of many other genes, with 1,113 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FLCN-associated genes across cancer lineages are MIR548AW, MIR3646, and OR2AD1P. Each is linked with FLCN in more than 2 cancer types. Because this analysis shows association rather than direction, both FLCN-to-partner and partner-to-FLCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR548AW grouped by FLCN-low versus FLCN-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLCN→partner) and Y-score (partner→FLCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR548AW →	+0.211	+4.108	<.001	.007	3	3
BRCA	MIR3646 →	+0.269	+7.731	<.001	.009	3	2
HNSC	OR2AD1P →	+0.039	+4.655	<.001	.007	3	2
STAD	RNU7-133P →	+0.528	+4.184	.008	.009	3	2
UCEC	AKIP1 →	+0.449	+2.724	.001	.003	3	2
UCEC	RNA5SP412 →	+0.506	+2.074	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,113 associations by consensus.

MIR548AW by FLCN expression — LUAD

Explore this box plot interactively →