FLCN

Across TCGA pan-cancer cohorts, FLCN RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of FLCN’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FLCN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FLCN is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

HNSC, KIRC, and LUAD are the cancer types where FLCN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FLCN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.916	<.001	12	view →
KIRC	Male	IV	+0.700	<.001	11	view →
LUAD	Female	III,IV	−0.881	<.001	9	view →
KIRP	All	All	+0.666	<.001	7	view →
LIHC	All	II,III,IV	+0.630	<.001	7	view →
LUSC	All	All	−0.483	<.001	6	view →
CHOL	Female	All	+1.276	<.001	5	view →
BRCA	All	All	−0.319	<.001	4	view →
STAD	Male	II,III,IV	+0.613	.011	3	view →
BLCA	Male	IV	−0.614	.009	1	view →
THCA	All	All	−0.191	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

FLCN–HNSC

Open the HNSC breakdown →