FKBP6

Across TCGA patient cohorts, FKBP6 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FKBP6-associated genes across cancer lineages are Stathmin, PCNA, and TFRC. Each is linked with FKBP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both FKBP6-to-partner and partner-to-FKBP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Stathmin grouped by FKBP6-low versus FKBP6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FKBP6→partner) and Y-score (partner→FKBP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Stathmin →	+0.204	+2.832	.047	.034	3	2
UCEC	PCNA →	+0.212	+2.321	.014	.033	3	2
UCEC	TFRC →	+0.431	+2.999	.043	.035	3	2
SKCM	N-Ras →	+0.155	+3.000	.046	.036	3	1
SKCM	CD20 →	-0.157	-3.000	.048	.036	3	1
UCEC	EGFR_pY1068 →	-0.265	-1.906	.008	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Stathmin by FKBP6 expression — SKCM

Explore this box plot interactively →