FIGNL1

Across TCGA patient cohorts, FIGNL1 mutation is significantly associated with the RNA expression of many other genes, with 2,013 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FIGNL1-associated genes across cancer lineages are AKIRIN1P2, RPS17P14, and NDUFS6P1. Each is linked with FIGNL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FIGNL1-to-partner and partner-to-FIGNL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AKIRIN1P2 grouped by FIGNL1-low versus FIGNL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FIGNL1→partner) and Y-score (partner→FIGNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AKIRIN1P2 →	+0.137	+1.664	.007	.002	3	3
SKCM	RPS17P14 →	+0.093	+3.330	.005	.004	3	2
LUAD	NDUFS6P1 →	+0.111	+4.612	<.001	.006	3	2
LUAD	SPATA31E3P →	+0.009	+4.399	<.001	.008	3	2
COAD	RNU6-986P →	+0.876	+4.101	<.001	<.001	3	2
COAD	SMSP1 →	+0.150	+4.383	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,013 associations by consensus.

AKIRIN1P2 by FIGNL1 expression — UCEC

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